The BADER Lab was recently awarded a pilot grant through the Institute for Translational Medicine (ITM) for their project, “Development of chronic deep vein thrombosis model for testing an ultrasound-based thrombectomy system.” These funds were allocated by the ITM to offer researchers more money, new resources, and collaboration opportunities with stakeholders ranging from industry to community members. The overall goal of this study is to establish a chronic thrombus in the femoral vein of a pig. Further, they aim to validate the efficacy of histotripsy, an ultrasound therapy that ablates tissue with the mechanical action of bubble clouds, combined with a thrombolytic drug in this porcine model of chronic venous thrombosis.
BADER Lab awarded pilot grant by ITM
Proposed implementation of histotripsy for the treatment of venous thrombosis. In addition to the standard-of-care catheter-infusion of the thrombolytic drug recombinant tissue plasminogen activator (rt-PA), histotripsy will be applied. Bubbles generated by the histotripsy ultrasound pulses will break down erythrocytes within in the thrombus, and improve the delivery of rt-PA to increase fibrin degradation.
