The focus of the Biomedical Acoustics Development and Engineering Research Laboratory (BADER Lab) is the translation of therapeutic ultrasound for non- or minimally invasive treatment of cardiovascular and cancerous disease. Specifically, we utilize acoustic cavitation for combinatorial ablation and enhanced drug delivery treatment strategies of pathologies resistant to standard interventional techniques. To assess bubble activity and the resultant changes in tissue structure, we are developing multi-modal imaging approaches via diagnostic ultrasound and magnetic resonance imaging. Analytic and numerical bubble dynamics models are also utilized to gain insight into the mechanism of action of our therapeutic approaches. Current research topics include:
• Chronic thrombus ablation with histotripsy and thrombolytic drugs
• Passive cavitation and MR imaging to assess histotripsy-induced liquefaction
• In vitro assessment of histotripsy-enhanced drug delivery
• Histotripsy-induced sonochemical reactions for the treatment of cancer
• Numeric and analytic models of bubble dynamics
• Magnetic Resonance-guided transurethral prostate ablation
For more information, visit our laboratory website: baderlab.uchicago.edu
University of Mississippi
Oxford, MS
Ph.D. - Physics
2011
Grand Valley State University
Allendale, MI
B.S. - Physics
2005
Assessment of Collaborative Robot (Cobot)-Assisted Histotripsy for Venous Clot Ablation.
Bader KB, Hendley SA, Bollen V. Assessment of Collaborative Robot (Cobot)-Assisted Histotripsy for Venous Clot Ablation. IEEE Trans Biomed Eng. 2021 04; 68(4):1220-1228.
PMID: 32915723
Clot degradation under the action of histotripsy bubble activity and a lytic drug.
Hendley SA, Paul JD, Maxwell AD, Haworth KJ, Holland CK, Bader KB. Clot degradation under the action of histotripsy bubble activity and a lytic drug. IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Jan 18; PP.
PMID: 33460375
In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA.
Bollen V, Hendley SA, Paul JD, Maxwell AD, Haworth KJ, Holland CK, Bader KB. In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA. Ultrasound Med Biol. 2020 02; 46(2):336-349.
PMID: 31785841
Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo.
Anthony GJ, Bollen V, Hendley S, Antic T, Sammet S, Bader KB. Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo. Phys Med Biol. 2019 05 02; 64(9):095023.
PMID: 30921780
MRI-guided transurethral insonation of silica-shell phase-shift emulsions in the prostate with an advanced navigation platform.
Anthony GJ, Bader KB, Wang J, Zamora M, Ostdiek A, Antic T, Krueger S, Weiss S, Trogler WC, Blair SL, Kummel AC, Sammet S. MRI-guided transurethral insonation of silica-shell phase-shift emulsions in the prostate with an advanced navigation platform. Med Phys. 2019 Feb; 46(2):774-788.
PMID: 30414276