The focus of the Biomedical Acoustics Development and Engineering Research Laboratory (BADER Lab) is the translation of therapeutic ultrasound for non- or minimally invasive treatment of cardiovascular and cancerous disease. Specifically, we utilize acoustic cavitation for combinatorial ablation and enhanced drug delivery treatment strategies of pathologies resistant to standard interventional techniques. To assess bubble activity and the resultant changes in tissue structure, we are developing multi-modal imaging approaches via diagnostic ultrasound and magnetic resonance imaging. Analytic and numerical bubble dynamics models are also utilized to gain insight into the mechanism of action of our therapeutic approaches. Current research topics include:
• Chronic thrombus ablation with histotripsy and thrombolytic drugs
• Passive cavitation and MR imaging to assess histotripsy-induced liquefaction
• In vitro assessment of histotripsy-enhanced drug delivery
• Histotripsy-induced sonochemical reactions for the treatment of cancer
• Numeric and analytic models of bubble dynamics
• Magnetic Resonance-guided transurethral prostate ablation
For more information, visit our laboratory website: baderlab.uchicago.edu
University of Mississippi
Oxford, MS
Ph.D. - Physics
2011
Grand Valley State University
Allendale, MI
B.S. - Physics
2005
In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA.
Bollen V, Hendley SA, Paul JD, Maxwell AD, Haworth KJ, Holland CK, Bader KB. In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA. Ultrasound Med Biol. 2020 Feb; 46(2):336-349.
PMID: 31785841
In vitro assessment of stiffness-dependent histotripsy bubble cloud activity in gel phantoms and blood clots.
Hendley SA, Bollen V, Anthony GJ, Paul JD, Bader KB. In vitro assessment of stiffness-dependent histotripsy bubble cloud activity in gel phantoms and blood clots. Phys Med Biol. 2019 07 18; 64(14):145019.
PMID: 31146275
Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.
Bader KB, Hendley SA, Anthony GJ, Bollen V. Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging. Phys Med Biol. 2019 05 29; 64(11):115012.
PMID: 30995623
Corrigendum to: "Shaken and Stirred: Mechanisms of Ultrasound-Enhanced Thrombolysis" in Ultrasound Med Biol 2015; 41(1): 187-196.
Bader KB, Gruber MJ, Holland CK. Corrigendum to: "Shaken and Stirred: Mechanisms of Ultrasound-Enhanced Thrombolysis" in Ultrasound Med Biol 2015; 41(1): 187-196. Ultrasound Med Biol. 2019 Aug; 45(8):2266.
PMID: 31126714
Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo.
Anthony GJ, Bollen V, Hendley S, Antic T, Sammet S, Bader KB. Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo. Phys Med Biol. 2019 05 02; 64(9):095023.
PMID: 30921780
For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy.
Bader KB, Vlaisavljevich E, Maxwell AD. For Whom the Bubble Grows: Physical Principles of Bubble Nucleation and Dynamics in Histotripsy Ultrasound Therapy. Ultrasound Med Biol. 2019 05; 45(5):1056-1080.
PMID: 30922619
MRI-guided transurethral insonation of silica-shell phase-shift emulsions in the prostate with an advanced navigation platform.
Anthony GJ, Bader KB, Wang J, Zamora M, Ostdiek A, Antic T, Krueger S, Weiss S, Trogler WC, Blair SL, Kummel AC, Sammet S. MRI-guided transurethral insonation of silica-shell phase-shift emulsions in the prostate with an advanced navigation platform. Med Phys. 2019 Feb; 46(2):774-788.
PMID: 30414276
The influence of gas diffusion on bubble persistence in shock-scattering histotripsy.
Bader KB, Bollen V. The influence of gas diffusion on bubble persistence in shock-scattering histotripsy. J Acoust Soc Am. 2018 06; 143(6):EL481.
PMID: 29960422
The influence of medium elasticity on the prediction of histotripsy-induced bubble expansion and erythrocyte viability.
Bader KB. The influence of medium elasticity on the prediction of histotripsy-induced bubble expansion and erythrocyte viability. Phys Med Biol. 2018 05 02; 63(9):095010.
PMID: 29553049
Post Hoc Analysis of Passive Cavitation Imaging for Classification of Histotripsy-Induced Liquefaction in Vitro.
Bader KB, Haworth KJ, Maxwell AD, Holland CK. Post Hoc Analysis of Passive Cavitation Imaging for Classification of Histotripsy-Induced Liquefaction in Vitro. IEEE Trans Med Imaging. 2018 01; 37(1):106-115.
PMID: 28783627