The focus of the Biomedical Acoustics Development and Engineering Research Laboratory (BADER Lab) is the translation of therapeutic ultrasound for non- or minimally invasive treatment of cardiovascular and cancerous disease. Specifically, we utilize acoustic cavitation for combinatorial ablation and enhanced drug delivery treatment strategies of pathologies resistant to standard interventional techniques. To assess bubble activity and the resultant changes in tissue structure, we are developing multi-modal imaging approaches via diagnostic ultrasound and magnetic resonance imaging. Analytic and numerical bubble dynamics models are also utilized to gain insight into the mechanism of action of our therapeutic approaches. Current research topics include:
• Chronic thrombus ablation with histotripsy and thrombolytic drugs
• Passive cavitation and MR imaging to assess histotripsy-induced liquefaction
• In vitro assessment of histotripsy-enhanced drug delivery
• Histotripsy-induced sonochemical reactions for the treatment of cancer
• Numeric and analytic models of bubble dynamics
• Magnetic Resonance-guided transurethral prostate ablation
For more information, visit our laboratory website: baderlab.uchicago.edu
University of Mississippi
Oxford, MS
Ph.D. - Physics
2011
Grand Valley State University
Allendale, MI
B.S. - Physics
2005
Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy.
Maxwell AD, Haworth KJ, Holland CK, Hendley SA, Kreider W, Bader KB. Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy. IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Sep 17; PP.
PMID: 34534078
Clot Degradation Under the Action of Histotripsy Bubble Activity and a Lytic Drug.
Hendley SA, Paul JD, Maxwell AD, Haworth KJ, Holland CK, Bader KB. Clot Degradation Under the Action of Histotripsy Bubble Activity and a Lytic Drug. IEEE Trans Ultrason Ferroelectr Freq Control. 2021 09; 68(9):2942-2952.
PMID: 33460375
Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging.
Bader KB, Wallach EL, Shekhar H, Flores-Guzman F, Halpern HJ, Hernandez SL. Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging. Phys Med Biol. 2021 Aug 05; 66(16).
PMID: 34271560
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug.
Bhargava A, Hendley SA, Bader KB. An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug. J Vis Exp. 2021 06 04; (172).
PMID: 34152319
Assessment of Collaborative Robot (Cobot)-Assisted Histotripsy for Venous Clot Ablation.
Bader KB, Hendley SA, Bollen V. Assessment of Collaborative Robot (Cobot)-Assisted Histotripsy for Venous Clot Ablation. IEEE Trans Biomed Eng. 2021 04; 68(4):1220-1228.
PMID: 32915723
In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA.
Bollen V, Hendley SA, Paul JD, Maxwell AD, Haworth KJ, Holland CK, Bader KB. In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA. Ultrasound Med Biol. 2020 02; 46(2):336-349.
PMID: 31785841
In vitro assessment of stiffness-dependent histotripsy bubble cloud activity in gel phantoms and blood clots.
Hendley SA, Bollen V, Anthony GJ, Paul JD, Bader KB. In vitro assessment of stiffness-dependent histotripsy bubble cloud activity in gel phantoms and blood clots. Phys Med Biol. 2019 07 18; 64(14):145019.
PMID: 31146275
Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.
Bader KB, Hendley SA, Anthony GJ, Bollen V. Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging. Phys Med Biol. 2019 05 29; 64(11):115012.
PMID: 30995623
Corrigendum to: "Shaken and Stirred: Mechanisms of Ultrasound-Enhanced Thrombolysis" in Ultrasound Med Biol 2015; 41(1): 187-196.
Bader KB, Gruber MJ, Holland CK. Corrigendum to: "Shaken and Stirred: Mechanisms of Ultrasound-Enhanced Thrombolysis" in Ultrasound Med Biol 2015; 41(1): 187-196. Ultrasound Med Biol. 2019 Aug; 45(8):2266.
PMID: 31126714
Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo.
Anthony GJ, Bollen V, Hendley S, Antic T, Sammet S, Bader KB. Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo. Phys Med Biol. 2019 05 02; 64(9):095023.
PMID: 30921780