The focus of the Biomedical Acoustics Development and Engineering Research Laboratory (BADER Lab) is the translation of therapeutic ultrasound for non- or minimally invasive treatment of cardiovascular and cancerous disease. Specifically, we utilize acoustic cavitation for combinatorial ablation and enhanced drug delivery treatment strategies of pathologies resistant to standard interventional techniques. To assess bubble activity and the resultant changes in tissue structure, we are developing multi-modal imaging approaches via diagnostic ultrasound and magnetic resonance imaging. Analytic and numerical bubble dynamics models are also utilized to gain insight into the mechanism of action of our therapeutic approaches. Current research topics include:
• Chronic thrombus ablation with histotripsy and thrombolytic drugs
• Passive cavitation and MR imaging to assess histotripsy-induced liquefaction
• In vitro assessment of histotripsy-enhanced drug delivery
• Histotripsy-induced sonochemical reactions for the treatment of cancer
• Numeric and analytic models of bubble dynamics
• Magnetic Resonance-guided transurethral prostate ablation
For more information, visit our laboratory website: baderlab.uchicago.edu
University of Mississippi
Oxford, MS
Ph.D. - Physics
2011
Grand Valley State University
Allendale, MI
B.S. - Physics
2005
Effect of Thrombin and Incubation Time on Porcine Whole Blood Clot Elasticity and Recombinant Tissue Plasminogen Activator Susceptibility.
Zemzemi C, Phillips M, Vela DC, Hilvert NA, Racadio JM, Bader KB, Haworth KJ, Holland CK. Effect of Thrombin and Incubation Time on Porcine Whole Blood Clot Elasticity and Recombinant Tissue Plasminogen Activator Susceptibility. Ultrasound Med Biol. 2022 08; 48(8):1567-1578.
PMID: 35644763
Histotripsy Bubble Cloud Contrast With Chirp-Coded Excitation in Preclinical Models.
Wallach EL, Shekhar H, Flores-Guzman F, Hernandez SL, Bader KB. Histotripsy Bubble Cloud Contrast With Chirp-Coded Excitation in Preclinical Models. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 02; 69(2):787-794.
PMID: 34748487
(More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy.
Hendley SA, Bhargava A, Holland CK, Wool GD, Ahmed O, Paul JD, Bader KB. (More than) doubling down: Effective fibrinolysis at a reduced rt-PA dose for catheter-directed thrombolysis combined with histotripsy. PLoS One. 2022; 17(1):e0261567.
PMID: 34982784
Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy.
Maxwell AD, Haworth KJ, Holland CK, Hendley SA, Kreider W, Bader KB. Design and Characterization of an Ultrasound Transducer for Combined Histotripsy-Thrombolytic Therapy. IEEE Trans Ultrason Ferroelectr Freq Control. 2022 01; 69(1):156-165.
PMID: 34534078
Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi.
Hendley SA, Dimov A, Bhargava A, Snoddy E, Mansour D, Afifi RO, Wool GD, Zha Y, Sammet S, Lu ZF, Ahmed O, Paul JD, Bader KB. Assessment of histological characteristics, imaging markers, and rt-PA susceptibility of ex vivo venous thrombi. Sci Rep. 2021 11 23; 11(1):22805.
PMID: 34815441
Histotripsy bubble cloud contrast with chirp-coded excitation in pre-clinical models.
Wallach EL, Shekhar H, Flores-Guzman F, Hernandez SL, Bader KB. Histotripsy bubble cloud contrast with chirp-coded excitation in pre-clinical models. IEEE Trans Ultrason Ferroelectr Freq Control. 2021 Nov 08; PP.
PMID: 34748487
Ultrasound for Aesthetic Applications: A Review of Biophysical Mechanisms and Safety.
Bader KB, Makin IRS, Abramowicz JS. Ultrasound for Aesthetic Applications: A Review of Biophysical Mechanisms and Safety. J Ultrasound Med. 2022 Jul; 41(7):1597-1607.
PMID: 34709673
Clot Degradation Under the Action of Histotripsy Bubble Activity and a Lytic Drug.
Hendley SA, Paul JD, Maxwell AD, Haworth KJ, Holland CK, Bader KB. Clot Degradation Under the Action of Histotripsy Bubble Activity and a Lytic Drug. IEEE Trans Ultrason Ferroelectr Freq Control. 2021 09; 68(9):2942-2952.
PMID: 33460375
Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging.
Bader KB, Wallach EL, Shekhar H, Flores-Guzman F, Halpern HJ, Hernandez SL. Estimating the mechanical energy of histotripsy bubble clouds with high frame rate imaging. Phys Med Biol. 2021 08 05; 66(16).
PMID: 34271560
An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug.
Bhargava A, Hendley SA, Bader KB. An In vitro System to Gauge the Thrombolytic Efficacy of Histotripsy and a Lytic Drug. J Vis Exp. 2021 06 04; (172).
PMID: 34152319