I have developed new approaches to functional and anatomic magnetic resonance imaging for over 30 years. I’ve applied these methods to improve detection and accurate diagnosis of cancer, and monitor cancer response to therapy. I am the Director of Magnetic Resonance Imaging Research at the University of Chicago, and Co-Director of the Advanced Imaging Program of the University of Chicago Comprehensive Cancer center. I’ve collaborated with our outstanding mammographic group and medical physics colleagues for many years to build internationally recognized research program in quantitative breast cancer MR imaging – which parallels and compliments a leading clinical program in breast cancer diagnosis and management. Similarly, I’ve collaborated with Dr. Oto and others to develop a leading translational research program focused on improving prostate cancer screening with MRI, and using MRI to guide therapye. With these collaborators, I’ve made pioneering contributions to MRI methods that improve prostate and breast cancer diagnosis and treatment. My research includes use of pre-clinical methods for breast and prostate cancer to improve understanding of cancer biology and guide the development of improved clinical methods.
University of California at Berkeley
Berkeley, CA
Ph.D. - Physical Chemistry
1984
Reed College
Portland
B.A - Physical Chemistry
1977
High spectral and spatial resolution MRI of prostate cancer: a pilot study.
Medved M, Chatterjee A, Devaraj A, Harmath C, Lee G, Yousuf A, Antic T, Oto A, Karczmar GS. High spectral and spatial resolution MRI of prostate cancer: a pilot study. Magn Reson Med. 2021 09; 86(3):1505-1513.
PMID: 33963782
Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images.
Gertsenshteyn I, Epel B, Barth E, Leoni L, Markiewicz E, Tsai HM, Fan X, Giurcanu M, Bodero D, Zamora M, Sundramoorthy S, Kim H, Freifelder R, Bhuiyan M, Kucharski A, Karczmar G, Kao CM, Halpern H, Chen CT. Improving Tumor Hypoxia Location in 18F-Misonidazole PET with Dynamic Contrast-enhanced MRI Using Quantitative Electron Paramagnetic Resonance Partial Oxygen Pressure Images. Radiol Imaging Cancer. 2021 03; 3(2):e200104.
PMID: 33817651
Signal intensity form of the Tofts model for quantitative analysis of prostate dynamic contrast enhanced MRI data.
Fan X, Chatterjee A, Medved M, Oto A, Karczmar GS. Signal intensity form of the Tofts model for quantitative analysis of prostate dynamic contrast enhanced MRI data. Phys Med Biol. 2021 01 22; 66(2):025002.
PMID: 33181487
Comparison of DCE-MRI of murine model cancers with a low dose and high dose of contrast agent.
Zhou X, Fan X, Mustafi D, Pineda F, Markiewicz E, Zamora M, Sheth D, Olopade OI, Oto A, Karczmar GS. Comparison of DCE-MRI of murine model cancers with a low dose and high dose of contrast agent. Phys Med. 2021 Jan; 81:31-39.
PMID: 33373779
Signal intensity form of the Tofts model for quantitative analysis of prostate dynamic contrast enhanced MRI data.
Fan X, Chatterjee A, Medved M, Oto A, Karczmar GS. Signal intensity form of the Tofts model for quantitative analysis of prostate dynamic contrast enhanced MRI data. Phys Med Biol. 2020 Nov 12.
PMID: 33181487
T2*-weighted MRI as a non-contrast-enhanced method for assessment of focal laser ablation zone extent in prostate cancer thermotherapy.
Sun C, Wang S, Chatterjee A, Medved M, Eggener S, Karczmar GS, Oto A. T2*-weighted MRI as a non-contrast-enhanced method for assessment of focal laser ablation zone extent in prostate cancer thermotherapy. Eur Radiol. 2021 Jan; 31(1):325-332.
PMID: 32785769
Magnetic resonance angiography reveals increased arterial blood supply and tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer.
Mustafi D, Valek R, Fitch M, Werner V, Fan X, Markiewicz E, Fernandez S, Zamora M, Mueller J, Olopade OI, Conzen SD, Brady MJ, Karczmar GS. Magnetic resonance angiography reveals increased arterial blood supply and tumorigenesis following high fat feeding in a mouse model of triple-negative breast cancer. NMR Biomed. 2020 10; 33(10):e4363.
PMID: 32881124
Sensitivity to myelin using model-free analysis of the water resonance line-shape in postmortem mouse brain.
Foxley S, Wildenberg G, Sampathkumar V, Karczmar GS, Brugarolas P, Kasthuri N. Sensitivity to myelin using model-free analysis of the water resonance line-shape in postmortem mouse brain. Magn Reson Med. 2021 02; 85(2):667-677.
PMID: 32783262
Discrimination of benign from malignant breast lesions in dense breasts with model-based analysis of regions-of-interest using directional diffusion-weighted images.
Penn AI, Medved M, Dialani V, Pisano ED, Cole EB, Brousseau D, Karczmar GS, Gao G, Reich BD, Abe H. Discrimination of benign from malignant breast lesions in dense breasts with model-based analysis of regions-of-interest using directional diffusion-weighted images. BMC Med Imaging. 2020 06 09; 20(1):61.
PMID: 32517657
Patient-Specific Characterization of Breast Cancer Hemodynamics Using Image-Guided Computational Fluid Dynamics.
Wu C, Hormuth DA, Oliver TA, Pineda F, Lorenzo G, Karczmar GS, Moser RD, Yankeelov TE. Patient-Specific Characterization of Breast Cancer Hemodynamics Using Image-Guided Computational Fluid Dynamics. IEEE Trans Med Imaging. 2020 09; 39(9):2760-2771.
PMID: 32086203