Yonglin Pu

Professor of Radiology

Phone: 773.834.7629


Medical school: Beijing Medical University, Beijing, P.R.China, 1984
PhD: Radiology, Beijing Medical University, Beijing, P.R.China, 1989
Radiology, Beijing Medical University, Beijing, P.R.China, 1989
Radiology, Weil Medical College of Cornell University, New York, NY, 2004
Nuclear Medicine, Mallinckrodt Institute of Radiology at Washington University, St. Louis, MO, 2003
American Board of Radiology, 2008
American Board of Nuclear Cardiology, 2005
American Board of Nuclear Medicine, 2003, Recertified in 2011

Recent Service/Awards

  • Associate Investigator, University of Chicago Cancer Research Center
  • Self-Assessment Module (SAM) reviewer for The American Board of Radiology.
  • Marc Tetalman Award for Outstanding Teaching, Department of Radiology, University of Chicago
  • Grant reward from NIH, NCI (R21): Developing a PET Volumetric Staging System for NSCLC: a Complement to TNM Staging.
  • Editorial Boards:
  1. Chinese Journal of Cancer Research
  2. Journal of Radiology & Radiation Therapy
  • Manuscript reviewer:
  1. Liver Transplantation
  2. Ophthalmic Plastic and Reconstructive Surgery
  3. Journal of Nuclear Medicine
  4. European Journal of Nuclear Medicine and Molecular Imaging.
  5. Proceedings of the National Academy of Sciences (PNAS)
  6. International Journal of Computer Assisted Radiology and Surgery
  7. PLOS ONE.
  8. Academic Radiology.
  9. Cancer Control Journal: Journal of the Moffitt Cancer Center.
  10. . Medical Physics: Since January 12, 2013
  11.  International Journal of Radiation Oncology, Biology, Physics
  12.  Lung Cancer Management published by Future Medicine
  13.  Pediatric Blood & Cancer
  14.  MedEdPORTAL Publications
  15.  Theranostics
  16.  American Journal of Respiratory and Critical Care Medicine

Clinical Interests

PET/CT oncology, Radiotherapy, Nuclear Cardiology, Neurologic Nuclear Medicine, SPECT/CT, Bone Scintigraphy

Research Interests

PET imaging of Lung cancer, Computer Aided Diagnosis (CAD), Dopamineric scintigraphy, Oncology PET clinical trials.

Selected Publications

  • Liu Y, Pu Y, Fox PT and Gao J-H. Quantification of dynamic changes in cerebral oxygenation with phase imaging at 1.9T. Magnetic Resonance in Medicine. 1999;41:407-411.
  • Liu HL, Pu Y, Liu Y, Nickerson LD, Andrews T, Fox PT, Gao J-H. Cerebral blood flow measurement by dynamic contrast MRI using singular value decomposition with an adaptive threshold. Magn Reson Med 1999; 42:167-172.
  • Liu Y, Gao JH, Liotto M, Pu Y, Fox PT. Temporal dissociation of parallel processing in human subcortical outputs. Nature 1999:400(22):364-367.
  • Matsuda M, Liu Y, Mahankali S, Pu Y, Mahankali A, Wang J, DeFronzo RA, Fox PT, and Gao J-H, Altered Brain Function after Oral Glucose Intake in Obese Non-Diabetic Humans Diabetes  1999;48(9):1801-06.
  • Pu Y, Li Q-F, Luo D-X, Zeng C-M, Gao J, Mahankali S, Fox PT, Gao. Increased detectability of Alpha Brain Glutamate/Glutamine in Neonatal Hypoxic-Ischemic Encephalopathy. American Journal of Neuroradiology (AJNR)  2000;21:203-212.
  • Mahankali S, Liu Y, Pu Y,  Wang J, Chen C, Fox PT and Gao J-H In vivo fMRI demonstration of hypothalamic function following intraperitoneal glucose administration in a rat model.  Magnetic Resonance in Medicine. 2000;43:155-159.
  • Pu Y, Yijun Liu, Jinwen Hou, Peter T. Fox, Jia-Hong Gao. Demonstration of the medullary lamellae of the human red nucleus with high resolution gradient echo MRI. American Journal of Neuroraiolog(AJNR) 2000;21:1243-47.
  • Tan LH, Spinks JA, Gao J-H, Liu HL, Perfetti CA, Xiong J, Stofer KA, Pu Y, Liu Y, Fox PT. Brain activation in the processing of Chinese characters and words: An functional MRI study. Human Brain Mapping 2000; 10:16-27 
  • Liu HL, Pu Y, Liu Y, Nickerson LD, Fox PT, Gao J-H. Comparison of temporal response in perfusion and BOLD based event-related functional MRI. Magn Reson Med 2000; 43:768-772.
  • Liu Y, Pu Y,  Gao J-H, Parsons LM, Xiong J, Liotti M, Bower JM, Fox PT Red Nucleus and Lateral Lateral Cerebellum supporting roles for sensory discrimination. Human Brain Mapping. 2000;10: 147-159.
  • Yee SH, Liu HL, Pu Y, Hou J, Fox PT, Gao J-H.  Detection of the brain response during a cognitive task using perfusion-based event-related functional MRI.  NeuroReport 2000;11(11):2533-2536.
  • Pu Y, Liu HL, Spinks JA, Mahankali S, Xiong J, Feng CM, Tan LH, Fox PT, Gao JH.  Cerebral hemodynamic response in Chinese (first) and English (second) language processing revealed by event-related functional MRI. Magn Reson Imaging. 2001 Jun;19(5):643-7.
  • Liu HL. Kochunov P. Hou J. Pu Y. Mahankali S. Feng CM. Yee SH. Wan YL. Fox PT. Gao JH. Perfusion-weighted imaging of interictal hypoperfusion in temporal lobe epilepsy using FAIR-HASTE: comparison with H(2)(15)O PET measurements. Magnetic Resonance in Medicine. 2001;45(3):431-5.
  • Pu Y and Dehdashti F. The role of FDG-PET in the management of Patients with lung cancer. Contemporary Oncology 2002;1(9):1-8.
  • Murray JP, Liotti M, Ingmundson P, Pu Y, Zamaripa F,  Liu Y, Wolddorff MG, Gao JH, Fox, PT. Children’s Brain activation while viewing televised violence revealed by fMRI. Media Psychology. 2006; 8(1):25-37.
  • Nie YK, Li Q, Li F, Pu Y, Appelbaum A, Doi K. Diagnostic Accuracy of Lung Nodules: A Semi-automatic Computer-aided Method. J. Nucl. Med. 2006;47(7):1075-1080.
  • Shiraishi J, Appelbaum D, Pu Y, Li Q, Doi K. Development of a computer-aided diagnostic scheme for detection of interval changes in successive whole-body bone scans. Med Phys 2007; 34(1):25-36.
  • Shiraishi J, Appelbaum D, Pu Y, Li Q, Pesce L, and Doi K. Usefulness of Temporal Subtraction Images for Identification of Interval Changes in Successive Whole-Body Bone Scans: JAFROC Analysis of Radiologists’ Performance. Academic Radiology. 2007;14(8):959-966.
  • Pu Y, Mahankali S, Hou J, Li J, Lancaster J, Gao J-H, Appelbaum D and Fox PT. High Prevalence of Pineal Cysts in Normal Adults Demonstrated By High-Resolution MR Imaging. American Journal of Neuroradiology (AJNR) 2007;28(10):1706-1709.
  • Pu Y,Li QF, Zeng CM, Garg A, Corby R, Pu S, Gao JH. A Positive Correlation between Alpha Glutamate and Glutamine on Brain 1H-MRS and Neonatal Seizures in Moderate and Severe Hypoxic-Ischemic Encephalopathy. American Journal of Neuroradiology (AJNR) 2008; 29(2):216.
  • Huang YR, Chen CF, Huang YJ,  Pu Y, Qiang Li Y, Appelbaum DE. No Inter-observer Variability in 18F-FDG PET Maximal Standardized Uptake Value Measurements in Lymphoma. Ann Nucl Med Sci 2009;22:1-9.
  • Huang YE, Chen CF, Huang SF, Wang PW,  Pu Y. Primary Epithelioid Angiosarcoma of the Rib on 18F-FDG PET/CT Imaging: A Case Report. Ann Nucl Med Sci 2009;22:101-107. .
  • Ilkhchoui Y, Appelbaum DE and  Pu Y. FDG-PET/CT findings of a metastatic pituitary tumor. A Case Report.  Cancer Imaging. 2010: 10(1): 114-116. DOI: 10.1102/1470-7330.2010.0015
  • Huang YE, Chen CF, Huang YJ, Konda SD, Appelbaum DE, Pu Y. Interobserver variability among measurements of the maximum and mean standardized uptake values on (18)F-FDG PET/CT and measurements of tumor size on diagnostic CT in patients with pulmonary tumors. Acta Radiol. 2010 Sep;51(7):782-8. PubMed PMID: 20707663.
  • Huang YE, Pu Y, Huang YJ, Chen CF, Pu QH, Konda SD, Appelbaum DE. The utility of the nonattenuation corrected 18F-FDG PET images in the characterization of solitary pulmonary lesions. Nucl Med Commun. 2010 Nov;31(11):945-51. PubMed PMID: 20739905.
  • Shiraishi J, Appelbaum D, Pu Y, Engelmann R, Li Q, Doi K. Clinical Utility of Temporal Subtraction Images in Successive Whole-Body Bone Scans: Evaluation in a Prospective Clinical Study. J Digit Imaging. J Digit Imaging. 2011 Aug;24(4):680-7. PMID: 20730471
  • Liao S, Penney BC, Wroblewski K, Zhang H, Simon CA, Kampalath R,  Shih MC, Shimada N, Chen S,  Salgia R, Appelbaum DE, Suzuki K, Chen CT, Pu Y. Prognostic value of metabolic tumor burden on 18F-FDG PET in nonsurgical patients with non-small cell lung cancer. Eur J Nucl Med Mol Imaging 2012; 39(1): 27-38, DOI: 10.1007/s00259-011-1934-6
  • Liao S, Penney BC, Zhang H, Suzuki K, Pu Y. Prognostic Value of the Quantitative Metabolic Volumetric Measurement on 18F-FDG PET/CT in Stage IV Nonsurgical Small-cell Lung Cancer. Academic Radiology 2012: 19(1):69-77.
  • Zhang H, Wroblewski K, Appelbaum DE, Pu Y .  Independent prognostic value of whole-body metabolic tumor burden from FDG-PET in non-small cell lung cancer. International Journal of Computer Assisted Radiology and Surgery 2013: 8(2):181-191 (Featured on “Global Medical Discovery” 2013) .
  • Zhang H, Wroblewski K, Pu Y. Prognostic value of tumor burden measurement using the number of tumors in non-surgical patients with non-small cell lung cancer. Acta Radiol June 2012 53:561—568.
  • Zhang H, Wroblewski K, Liao S, Kampalath R, Penney BC, Zhang Y, Pu Y.  Prognostic Value of Metabolic Tumor Burden from 18F-FDG PET in Surgical Patients with Non-small-cell Lung Cancer. Academic Radiology 2013; 20:32-40 (Among the top 5 most downloaded paper of the journal in 2013).
  • Obara P and Pu Y. Prognostic value of metabolic tumor burden in lung cancer. Chin J Cancer Res. 2013; 25(6): 615–622.