Assistant Professor of Radiology
Undergraduate: BS, Physics, Grand Valley State University, 2005
Doctorate: PhD, Physics, University of Mississippi, 2011
- Member, Advisory Editorial Board, Ultrasound in Medicine and Biology
- Member, Biomedical Acoustics Technical Committee, Acoustical Society of America, 2011-Present
- Member, Physical Acoustics Technical Committee, Acoustical Society of America, 2005-Present
- Excellence in Outreach Award, Sigma Xi, 2016
- Focused Ultrasound Foundation Award (319R1), 2014-2015
Deep vein thrombosis is a debilitating condition that can require rapid intervention to prevent amputation of the affected limb or death. Standard interventional approaches are not effective for older, chronic thrombi, characteristic of those found in deep vein thrombosis. Histotripsy is a novel form of therapeutic ultrasound that employs the mechanical action of oscillating cavitation bubbles to ablate thrombi. Preliminary data from Dr. Bader demonstrates that the thrombolytic recombinant tissue plasminogen activator acts synergistically with histotripsy pulses to provide enhanced thrombolysis in a highly retracted venous clot in vitro. Further studies will elucidate the efficacy and potential risks of histotripsy to ablate venous thrombosis, and provide new information to assist the development of targeted ablation methods to improve thrombolysis in the treatment of currently intractable deep vein thrombosis.
Tissue ablation through the mechanical action of cavitation produces minimal thermal deposition. Thus, conventional techniques to monitor the treatment progress, such as magnetic resonance thermometry, fail for histotripsy. Emissions from the cavitation serve as a surrogate for the mechanical action of the cavitation. The amplitude of these emissions can be mapped with passive ultrasound, termed Passive Cavitation Imaging (PCI). Our preliminary data demonstrate that PCI is significantly more accurate and sensitive to mechanical ablation than B-mode ultrasound imaging. Combining PCI with magnetic resonance imaging would allow real-time monitoring of the cavitation and liquefaction of the target tissue.