Daniel Appelbaum, MD, is both a radiologist and nuclear medicine physician. He has expertise in the full spectrum of nuclear/molecular imaging, specializing in oncologic, neurologic, cardiac and positron emission tomographic (PET and PET/CT) applications. Dr. Appelbaum and his colleagues offer a full array of both diagnostic and therapeutic nuclear exams and procedures for adults and children at the University of Chicago Medicine.
Dr. Appelbaum conducts nuclear and molecular imaging research in the basic science and clinical settings. His current work involves development of a novel brain imaging agent for multiple sclerosis, as well as a metabolic catalyst to augment tumor detection with PET imaging. Other interests include developing new strategies for using computer-aided diagnosis (CAD) in nuclear medicine, work for which he has been awarded a patent in artificial intelligence (AI). The section he leads is involved in several oncology PET/CT clinical trials that monitor how patients respond to therapy. Dr. Appelbaum chairs the University of Chicago Radioactive Drug Research Advisory Committee (RADRAC).
An active educator, Dr. Appelbaum accepts many lecture invitations on nuclear and PET imaging at hospitals and medical meetings worldwide. He is a longstanding member of the national Society of Nuclear Medicine Committee on Education. He has also published a textbook (Nuclear Medicine RadCases) designed as a comprehensive review of his field.
Mallinckrodt Institute of Radiology at Washington University
St. Louis, MO
- Fellowship- Nuclear Medicine
2000
American Board of Nuclear Medicine
- Certification
2000
American Board of Radiology
- Certification
1999
University of Chicago
Chicago, IL
- Residency- Diagnostic Radiology
1999
Mount Sinai School of Medicine
New York, NY
MD
1995
Cornell University
Ithaca, NY
BA - English Literature
1991
MEN1/DAXX/ATRX mutations enhance progression-free survival in gastroenteropancreatic neuroendocrine tumors treated with peptide receptor radionuclide therapy.
MEN1/DAXX/ATRX mutations enhance progression-free survival in gastroenteropancreatic neuroendocrine tumors treated with peptide receptor radionuclide therapy. Endocr Relat Cancer. 2024 Nov 01; 31(11).
PMID: 39093924
Comparison of Measurement and Prognostic Power of SUV Between High-Definition and Standard PET Imaging in Non-Small Cell Lung Cancer Patients.
Comparison of Measurement and Prognostic Power of SUV Between High-Definition and Standard PET Imaging in Non-Small Cell Lung Cancer Patients. J Nucl Med Technol. 2024 Sep 05; 52(3):229-233.
PMID: 39019575
Calcified Fibrin Sheath Embolized to the Pulmonary Artery Mimicking a Retained Catheter Fragment.
Calcified Fibrin Sheath Embolized to the Pulmonary Artery Mimicking a Retained Catheter Fragment. J Vasc Interv Radiol. 2024 Jun; 35(6):943.
PMID: 38789208
Optimization of Metabolic Tumor Volume as a Prognostic Marker in CAR T-Cell Therapy for Aggressive Large B-cell NHL.
Optimization of Metabolic Tumor Volume as a Prognostic Marker in CAR T-Cell Therapy for Aggressive Large B-cell NHL. Clin Lymphoma Myeloma Leuk. 2024 02; 24(2):83-93.
PMID: 37827881
99m Technetium-pyrophosphate bone scan: A potential biomarker for the burden of transthyretin amyloidosis in skeletal muscle: A preliminary study.
99m Technetium-pyrophosphate bone scan: A potential biomarker for the burden of transthyretin amyloidosis in skeletal muscle: A preliminary study. Muscle Nerve. 2023 Feb; 67(2):111-116.
PMID: 36222831
Progressive Multiple Mononeuropathy in a Patient With Familial Transthyretin Amyloidosis After Liver Transplantation.
Progressive Multiple Mononeuropathy in a Patient With Familial Transthyretin Amyloidosis After Liver Transplantation. J Clin Neuromuscul Dis. 2022 Mar 01; 23(3):143-147.
PMID: 35188911
Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy in T-cell/histiocyte-rich large B-cell lymphoma.
Primary resistance to CD19-directed chimeric antigen receptor T-cell therapy in T-cell/histiocyte-rich large B-cell lymphoma. Blood. 2021 06 17; 137(24):3454-3459.
PMID: 33881502
Prevalence of newly diagnosed sarcoidosis in patients with ventricular arrhythmias: a cardiac magnetic resonance and 18F-FDG cardiac PET study.
Prevalence of newly diagnosed sarcoidosis in patients with ventricular arrhythmias: a cardiac magnetic resonance and 18F-FDG cardiac PET study. Int J Cardiovasc Imaging. 2021 Apr; 37(4):1361-1369.
PMID: 33225427
Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma.
Computer-assisted Curie scoring for metaiodobenzylguanidine (MIBG) scans in patients with neuroblastoma. Pediatr Blood Cancer. 2018 12; 65(12):e27417.
PMID: 30198643
Developing and validating a novel metabolic tumor volume risk stratification system for supplementing non-small cell lung cancer staging.
Developing and validating a novel metabolic tumor volume risk stratification system for supplementing non-small cell lung cancer staging. Eur J Nucl Med Mol Imaging. 2018 11; 45(12):2079-2092.
PMID: 29882161
"America's Top Doctor"
Castle Connolly
2014 - now
“Chicago’s Top Doctor”
Chicago Magazine
2012 - now
Marc Tetalman "Teacher of the Year" Award
The University of Chicago
2006 - 2007