Daniel E. Appelbaum

Professor of Radiology
Section Chief, Nuclear Medicine

Phone: 773.834.2012


Undergraduate: Cornell University, Ithaca, NY; BA English Literature 1991
Medical School: Mount Sinai School of Medicine, New York, NY; MD 1995
Residency: Diagnostic Radiology, University of Chicago, Chicago, IL, 1999
Fellowship: Nuclear Medicine, Mallinckrodt Institute of Radiology at Washington University, St. Louis, MO, 2000
American Board of Radiology, 1999
American Board of Nuclear Medicine, 2000


  • Associate Investigator, University of Chicago Cancer Research Center
  • Chair, Radioactive Drug Research Advisory Committee (RADRAC), University of Chicago
  • Course Director, University of Chicago Annual Radiology Review
  • Medical Director, Nuclear Medicine Technology Program, Triton College
  • American Board of Radiology, Maintenance of Certification (MOC) Committee
  • Society of Nuclear Medicine, Committee on Education (National)
  • Radiology Resident Selection Committee, University of Chicago
  • Nuclear medicine Subspecialty Education Chief, University of Chicago
  • Marc Tetalman Award for Outstanding Teaching, Department of Radiology, University of Chicago
  • “Chicago’s Top Doctor” Chicago Magazine, 2012 - Present
  • "America's Top Doctor" Castle Connolly, 2014 - Present

Clinical Interests

PET/CT oncology, Radiotherapy, Nuclear Cardiology, Neurologic Nuclear Medicine, SPECT/CT, Bone Scintigraphy

Research Interests

Computer Aided Diagnosis (CAD), Dopamineric scintigraphy, Multiple Sclerosis imaging, Oncology PET clinical trials

Selected Publications / Patents

  • Yacoub JH, Yousuf A, Agrawal G, Thomas S, Appelbaum DE, Oto, A. Evaluation of the gallbladder and cystic duct patency with gadoxetate disodium enhanced MR cholangiography: prospective comparison of patients with normal gallbladder function and acute cholecystitis. Acta Radiol published online 9 July 2014. DOI: 10.1177/0284185114538955
  • Chen JL, Appelbaum D, Kocherginsky M, Cowey CL, Rathmell WK, McDermott DF, Stadler W. FDG-PET as a Predictive Biomarker for Therapy With Everolimus in Metastatic Renal Cell Cancer (mRCC). Cancer Med. 2013 Aug;2(4):545-52. DOI: 10.1002/cam4.102.
  • Solanki AA, Weichselbaum RR, Appelbaum D, Farrey K, Yenice KM, Chmura SJ, Salama JK. The Utility of FDG-PET for Assessing Outcomes in Oligometastatic Cancer Patients Treated with Stereotactic Body Radiotherapy: A Cohort Study.  Radiat Oncol. 2012 Dec 18;7:216. DOI: 10.1186/1748-717X-7-216. PMID: 23244066
  • Zhang H, Wroblewski K, Appelbaum D, Pu Y. Independent Prognostic Value of Whole-Body Metabolic Tumor Burden from FDG-PET in Non-small Cell Lung Cancer. International Journal of Computer Assisted Radiology and Surgery, May 2012. DOI 10.1007/s11548-012-0749-7. PMID: 22644386
  • Shiraishi J, Li Q, Appelbaum D, Doi K, Computer-Aided Diagnosis and Artificial Intelligence in Clinical Imaging. Semin Nucl Med 41:449-462, October 2011. doi: 10.1053/j.semnuclmed.2011.06.004. PMID: 21978447
  • Nie YK, Li Q, Li F, Pu Y, Appelbaum DE, Doi K. Integrating PET and CT information to Improve Diagnostic Accuracy for Lung Nodules: A Semiautomatic Computer-Aided Method: J. Nucl. Med 2006 July; 47(10) 1075-1080. PMID: 16818939
  • Nuclear Medicine RadCases, Daniel Appelbaum, John Miliziano, Sundeep Nayak, and Yong Bradley, Thieme (232 pages), July 2011
  • USSN 14/329,597 (Use of Fluorinated Derivatives of 4-Aminopyridine in Therapeutics and Medical Imaging); Brugarolas P, Popko B, Appelbaum D, Chen C. Patent issued July 11, 2014
  • WO 2007/062135 A2 (Computer-Aided Method for Detection of Interval changes in Successive Whole-Body Bone Scans and Related Computer Program Product and System); Shiraishi J, Doi K, Appelbaum D, Li Q. Patent Issued May 31, 2007