Maryellen L. Giger - Publications

Selected Publications (1981-present; M. L. Giger is the author or coauthor of more than 200 publications):

  1. Lissak M, Wynn VT: The detection of low frequency rhythms in the electrocardiograms of male and female subjects. J. Interdiscipl. Cycle Res. 12: 69, 1981 .
  2. Giger ML, Doi K: Investigation of basic imaging properties in digital radiography. 1. Modulation transfer function. Medical Physics 11: 287-295, 1984.
  3. Giger ML, Doi K, Metz CE: Investigation of basic imaging properties in digital radiography. 2. Noise Wiener Spectrum. Medical Physics 11: 797-805, 1984.
  4. Giger ML, Doi K: Effect of pixel size on detectability of low-contrast signals in digital radiography. Journal of the Optical Society of America A 4: 966-975, 1987.
  5. Giger ML, Doi K, MacMahon H: Image feature analysis and computer-aided diagnoses in digital radiography. 3. Automated detection of nodules in peripheral lung fields. Medical Physics 15: 158-166, 1988.
  6. Fraser RG, Sanders C, Barnes GT, MacMahon H, Giger ML, Doi K, Templeton AW, Cox GG, Dwyer SJ, Merritt C, Jones J: Digital imaging of the chest: state of the art. Radiology 171: 297-307, 1989.
  7. Cook LT, Giger ML, Batnitzky S, Wetzel LH, Murphey MD: Digitized film radiography. Investigative Radiology 24: 910-916, 1989.
  8. Giger ML, Doi K, MacMahon H, Metz CE, Yin F-F: Computer-aided detection of pulmonary nodules in digital chest images. RadioGraphics 10: 41-51, 1990.
  9. Giger ML, Ahn N, Doi K, MacMahon H, Metz CE: Computerized detection of pulmonary nodules in digital chest images: Use of morphological filters in reducing false-positive detections. Medical Physics 17:861-865, 1990.
  10. Yin F-F, Giger ML, Doi K: Measurement of the presampling MTF of film digitizers using a curve fitting technique. Medical Physics 17: 962-966, 1990.
  11. Yin F-F, Giger ML, Doi K, Metz CE, Vyborny CJ, Schmidt RA: Computerized detection of masses in digital mammograms: Analysis of bilateral-subtraction images. Medical Physics 18: 955-963, 1991.
  12. Brailean JC, Little D, Giger ML, Chen C-T, Sullivan B: A performance evaluation of the EM algorithm applied to radiographic images. Medical Physics 19: 1175-1182, 1992.
  13. Wu Y, Doi K, Giger ML, Nishikawa RM: Computerized detection of clustered microcalcifications in digital mammograms: Applications of artificial neural networks. Medical Physics 19: 555-560, 1992.
  14. Matsumoto T, Yoshimura H, Doi K, Giger ML, Kano A, MacMahon H, Abe K, Montner SM: Image feature analysis of false-positive diagnoses produced by automated detection of lung nodules. Investigative Radiology 27: 587-597, 1992.
  15. Caligiuri P, Giger ML, Favus M, Jia H, Doi K, Dixon L: Computerized radiographic analysis of osteoporosis. Radiology 186: 471-474, 1993.
  16. Wu Y, Giger ML, Doi K, Vyborny CJ, Schmidt RA, Metz CE: Artificial neural networks in mammography: Application to decision making in the diagnosis of breast cancer. Radiology 187: 81-87, 1993.
  17. Bae KT, Giger ML, Chen CT, Kahn CE: Automatic segmentation of 3-D liver structure from CT data. Medical Physics 20: 71-78, 1993.
  18. Giger ML, Doi K, MacMahon H, Nishikawa RM, Hoffmann KR, et al.: An "intelligent" workstation for computer-aided diagnosis. RadioGraphics 13: 647-656, 1993.
  19. Giger ML, Vyborny CJ: CAD in mammography: rationale, methods and possible scenarios. Diagnostic Imaging June, 98-113, 1993.
  20. Nishikawa RM, Giger ML, Doi K, Vyborny CJ, Schmidt RA: Computer-aided detection of clustered microcalcifications: An improved method for grouping detected signals. Medical Physics 20: 1661-1666, 1993.
  21. Nishikawa RM, Giger ML, Doi K, Vyborny CJ: Effect of case selection on the performance of computer-aided detection schemes. Medical Physics 21: 265-269, 1994.
  22. Yin FF, Giger ML, Doi K, Vyborny CJ, Schmidt RA: Computerized detection of masses in digital mammograms: Automated alignment of breast images and its effect on bilateral-subtraction technique. Medical Physics 21: 445-452, 1994.
  23. Giger ML, Bae KT, MacMahon H: Computerized detection of pulmonary nodules in CT images. Investigative Radiology 29: 459-465, 1994.
  24. Caligiuri P, Giger ML, Favus M: Multifractal radiographic analysis of osteoporosis. Medical Physics 21: 503-508, 1994.
  25. Vyborny CJ, Giger ML: Computer vision and artificial intelligence in mammography. AJR 162: 699-708, 1994.
  26. Giger ML, Vyborny CJ, Schmidt RA: Computerized characterization of mammographic masses: Analysis of spiculation. Cancer Letters 77: 201-211, 1994.
  27. Kano A, Doi K, MacMahon H, Hassell DD, Giger ML: Digital image subtraction of temporally sequential chest images for detection of interval change. Medical Physics 21: 453-461, 1994.
  28. Wu Y, Doi K, Giger ML: Detection of lung nodules in digital chest radiographs using artificial neural networks: A pilot study. Journal of Digital Imaging 8: 88-94, 1995.
  29. Armato S, Giger ML, MacMahon H: Computerized detection of abnormal asymmetry
    1. in digital chest radiographs. Medical Physics 21: 1761-1768, 1994.
  30. Bick U, Giger ML, Schmidt RA, Nishikawa RM, Wolverton DE, Lu P, Vyborny CJ,
    1. a. Doi K: Automated segmentation of digitized mammograms. Academic Radiology 2: 1-9, 1995.
  31. Zhang W, Doi K, Giger ML, Nishikawa RM, Schmidt RA: An improved shift-invariant artificial neural network for computerized detection of clustered microcalcifications in digital mammograms. Medical Physics 23:595-601, 1995.
  32. Huo Z, Giger ML, Vyborny CJ, Bick U, Lu P, Wolverton DE, Schmidt RA: Analysis of spiculation in the computerized classification of mammographic masses" Medical Physics 22:1569-1579, 1995.
  33. Jiang Y, Nishikawa RM, Wolverton DE, Metz CE, Giger ML, Schmidt RA, Vyborny CJ, Doi K: Automated feature analysis and classification of malignant and benign clustered microcalcifications. Radiology 198:671-678, 1996.
  34. Yoshida H, Doi K, Nishikawa RM, Giger ML, Schmidt RA: An improved computer-assisted diagnostic scheme using wavelet transform for detecting clustered microcalcifications in digital mammograms. Academic Radiology 3: 621-627, 1996.
  35. Bick U, Giger ML, Schmidt RA, Nishikawa RM, Doi K: Peripheral density correction of digital mammographs. RadioGraphics 16:1403-1411, 1996.
  36. Armato S, Giger ML, MacMahon H, Chen CT, Vyborny CJ: Automated registration of ventilation/perfusion images with digital chest radiographis. Academic Radiology 4:183-192, 1997.
  37. Xu XW, Doi K, Kobayashi T, MacMahon H, Giger ML: Development of an improved CAD scheme for automated detection of lung nodules in digital chest images. Medical Physics 24:1395-1404, 1997.
  38. Huo Z, Giger ML, Vyborny CJ, Wolverton DE, Schmidt RA, Doi K: Automated computerized classification of malignant and benign mass lesions on digitized mammograms. Academic Radiology 5: 155-168, 1998.
  39. Armato SG, Giger ML, MacMahon H: Automated lung segmentation in digitized posteroanterior chest radiographs. Academic Radiology 5: 245-255, 1998.
  40. Armato SG, Giger ML, MacMahon H: Computerized delineation and analysis of costophrenic angles in digital chest radiographs. Academic Radiology 5: 329-335, 1998.
  41. Gilhuijs KGA, Giger ML, Bick U: Automated analysis of breast lesions in three dimensions using dynamic magnetic resonance imaging. Medical Physics 25:1647-1654, 1998.
  42. Kupinski MA, Giger ML: Automated seeded lesion segmentation on digital mammograms. IEEE Trans on Medical Imaging, 17: 510-517, 1998.
  43. Jiang Y, Nishikawa RM, Schmidt RA, Metz CE, Giger ML, Doi K: Improving breast cancer diagnosis with computer-aided diagnosis. Academic Radiology 6: 22-33, 1999.
  44. Giger ML, Al-Hallaq H, Huo A, Moran C, Wolverton DE, Chan CW, Zhong W: Computerized analysis of lesions in ultrasound images of the breast. Academic Radiology 6: 665-674, 1999.
  45. Huo Z, Giger ML, Metz CE: Effect of dominant features on neural network performance in the classification of mammographic lesions. PMB 44: 2579-2595, 1999.
  46. Jiang C, Giger ML, Chinander MR, Martell JM, Kwak S, Favus MJ: Characterization of bone quality using computer-extracted radiographic features. Medical Physics 26: 872-879, 1999.
  47. Kupinski MA, Giger ML: Feature selection with limited datasets. Medical Physics 26: 2176-2182, 1999.
  48. Chinander MR, Giger ML, Martell JM, Favus MJ: Computerized radiographic texture measures for characterizing bone strength: A simulated clinical setup using femoral neck specimens. Medical Physics 26: 2295-2300, 1999.
  49. Chinander MR, Giger ML, Martell JM, Favus MJ: Computerized analysis of radiographic bone patterns: Effect of imaging conditions on performance. Medical Physics 27: 75-85, 2000.
  50. Huo Z, Giger ML, Wolverton DE, Zhong W, Cumming S, Olopade OI: Computerized analysis of mammographic parenchymal patterns for breast cancer risk assessment: Feature selection. Medical Physics 27: 4-12, 2000.
  51. Armato SG III, Giger ML, Chen C-T, Vyborny CJ, Ryan J, and MacMahon H,: Automated registration of frontal and lateral radionuclide lung scans with digital chest radiographs. Academic Radiology 7: 530-539, 2000.
  52. Huo Z, Giger ML, Vyborny CJ, Wolverton DE, Metz CE: Computerized classification of benign and malignant masses on digitized mammograms: a robustness study. Academic Radiology 7:1077-1084, 2000.
  53. Armato SG III, Giger ML, MacMahon H: Automated detection of lung nodules in CT scans: Preliminary results. Medical Physics 28:1552-1561, 2001.
  54. Kupinski MA, Edwards DC, Giger ML, Metz CE: Ideal observer approximation using Bayesian classification neural networks. IEEE-Trans Medical Imaging, 20: 886-899, 2001.
  55. Horsch K, Giger ML, Venta LA, Vyborny CJ: Automatic segmentation of breast lesions on ultrasound. Medical Physics 28: 1652-1659, 2001.
  56. Giger ML: Computer-aided diagnosis in medical imaging -- A new era in image interpretation. Next-Generation Healthcare. World Medical Association General Assembly, World Markets Research Centre, pp 75-79, October, 2001.
  57. Huo Z, Giger ML, Vyborny CJ: Computerized analysis of multiple-mammographic views: Potential usefulness of special view mammograms in computer-aided diagnosis. IEEE Transactions on Medical Imaging 20: 1285-1292, 2001.
  58. Horsch K, Giger ML, Venta LA, Vyborny CJ: Computerized diagnosis of breast lesions on ultrasound. Medical Physics 29: 157-164, 2002.
  59. Huo Z, Giger ML, Vyborny CJ, Metz CE: Effectiveness of CAD in the diagnosis of breast cancer: An observer study on an independent database of mammograms Radiology 224:560-568, 2002.
  60. Armato SG III, Li F, Giger ML, MacMahon H, Sone S, Doi K: Performance of automated CT nodule detection on missed cancers from a lung cancer screening program. Radiology 225:685-692, 2002
  61. Huo Z, Giger ML, Olopade OI, Wolverton DE, Weber BL, Metz CE, Zhong W, Cummings S: Computerized analysis of digitized mammograms of BRCA1/BRCA2 gene mutation carriers. Radiology 225:519-526, 2002.
  62. Drukker K, Giger ML, Horsch K, Kupinski MA, Vyborny CJ, Mendelson EB: Computerized lesion detection on breast ultrasound. Medical Physics 29:1438-1446, 2002.
  63. Giger ML: Computerized image analysis in breast cancer detection and diagnosis. Seminars in Breast Disease 5:199-210, 2002.
  64. Carson PL, Giger ML, Welch MJ, et al.: Biomedical imaging research opportunities workshop: Report and recommendations. Radiology 229: 328-339, 2003.
  65. Edwards DC, Lan L, Metz CE, Giger ML, Nishikawa RM: Estimating three-class ideal observer decision variables for computerized detection and classification of mammographic mass lesions. Medical Physics 31: 81-90, 2004.
  66. Li H, Giger ML, Huo Z, Olopade OI, Lan L, Weber BL, Bonta I: Computerized Analysis of Mammographic Patterns for Assessing Breast Cancer Risk: Effect of ROI Size and Location, Medical Physics 31: 549-555, 2004.
  67. Chen W, Giger ML, Lan L, Bick U: Computerized interpretation of breast MRI: Investigation of enhancement-variance dynamics, Medical Physics 31: 1076-1082, 2004.
  68. Wilkie JR, Giger ML, Chinander MR, Vokes TJ, Nishikawa RM, Carlin MD: Investigation of physical image quality indices of a bone densitometry system. Medical Physics 31: 873-881, 2004.
  69. Wilkie JR, Giger ML, Chinander MR, Vokes TJ, Li H, Dixon L, Jaros V: Comparison of radiographic texture analysis from computed radiography and bone densitometry systems. Medical Physics 31: 882-891, 2004.
  70. Li H, Giger ML, Olopade O, Margolis A, Lan L, Chinander MR: Computerized texture analysis of mammographic parenchymal patterns of digitized mammograms. Academic Radiology 12: 863-873, 2005.
  71. Drukker K, Horsch K, Giger ML: Multimodality computerized diagnosis of breast lesions using mammography and sonography. Academic Radiology 12: 970-979, 2005.
  72. Partain CL, Chan HP, Gelovani JG, Giger ML, Izatt JA, et al.: Biomedical Imaging Research Opportunities Workshop II: Report and Recommendations. Radiology 236: 389-403, 2005.
  73. Drukker K, Giger ML, Metz CE: Robustness of computerized lesion detection and classification scheme across different breast ultrasound platforms. Radiology. 237: 834-840, 2005.
  74. Chen W, Giger ML, Bick U: A fuzzy c-means (FCM) based approach for computerized segmentation of breast lesions in dynamic contrast-enhanced MR images. Academic Radiology 13: 63-72, 2006.
  75. Reiser I, Nishikawa RM, Giger ML, Wu T, Rafferty EA, Moore R, Kopans DB: Computerized mass detection for digital breast tomosynthesis directly from the projection images. Medical Physics 33: 482-491, 2006.
  76. King M, Pan X, Yu L, Giger M: Region-of-interest reconstruction of motion-contaminated data using a weighted backprojection filtration algorithm. Medical Physics 33: 1222-1238, 2006.
  77. Vokes TJ, Giger ML, Chinander MR, Karrison TG, Gavus MJ, Dixon LB: Radiographic texture analysis of densitometer-generated calcaneous images differentiates postmenopausal women with and without fractures. Osteoporosis Int 17: 1472-1482, 2006.
  78. Horsch K, Giger ML, Vyborny CJ, Lan L, Mendelson EB, Hendrick RE: Classification of breast lesions with multi-modality computer-aided diagnosis: Observer study results on an independent clinical data set. Radiology 240: 357-368, 2006.
  79. Chen W, Giger ML, Bick U, Newstead G: Automatic identification and classification of characteristic kinetic curves of breast lesions on DCE-MRI. Medical Physics, 33: 2878-2887, 2006.
  80. Chen W, Giger ML, Li H, Bick U, Newstead: Volumetric texture analysis of breast lesions on contrast-enhanced magnetic resonance images. Magnetic Resonance in Medicine, 58: 562-571, 2007.
  81. Li H, Giger ML, Olopade OI, Lan L. Fractal Analysis of Mammographic Parenchymal Patterns in Breast Cancer Risk Assessment, Academic Radiology 14: 513-521, 2007. (Highlighted in BreastCancer.Net News of May 14, 2007 issue).
  82. Yuan Y, Giger ML, Li H, Suzuki K, Sennett C. A dual-stage method for lesion segmentation on digital mammograms, Medical Physics 34: 4180-4193, 2007.
  83. King M, Giger ML, Suzuki K, Pan X: Feature-based characterization of motion-contaminated calcified plaques in cardiac multidetector CT. Medical Physics 34: 4860-4875, 2007.
  84. King M, Giger ML, Suzuki K, Bardo DME, Greenberg B, Lan L, Pan X: Computerized assessment of motion-contaminated calcified plaques in cardiac multidetector CT. Medical Physics 34: 4876-4889, 2007.
  85. Wilkie J, Giger ML, Engh CA, Hopper RH, Martell JM: Radiographic texture analysis in the characterization of trabecular patterns in periprosthetic osteolysis. Academic Radiology 15: 176-185
  86. Wilkie J, Giger ML, Chinander MR, Engh CA, Hopper RH, Martell JM: Temporal radiographic texture analysis in the detection of periprosthetic osteolysis. Medical Physics 35: 377-387, 2008.
  87. Horsch K, Giger ML, Metz CE: Potential effect of different radiologists reporting methods on studies showing benefit of CAD. Academic Radiology 15: 139-152, 2008.
  88. Drukker K, Gruszauskas N, Sennett CA, Giger ML: Breast Ultrasound Computer-Aided Diagnosis: Performance on a Large Clinical Diagnostic Population, Radiology 248: 392-397, 2008.
  89. Li H, Giger ML, Olopade OI, Chinander MR, Power Spectral Analysis of Mammographic Parenchymal Patterns of Digitized Mammograms,” J of Digital Imaging 21: 145-152, 2008.
  90. Vokes TJ, Pham A, Wilkie J, Kocherginsky M, Ma SL, Chinander M, Karrison T, Bris O, Giger ML. Reproducibility and sources of variability in radiographic texture analysis of densitometric calcaneal images, J Clin Densitometry 11: 211-220, 2008.
  91. Horsch K, Giger ML, Metz CE: Prevalence Scaling: Applications to an Intelligent Workstation for the Diagnosis of Breast Cancer Academic Radiology, Academic Radiology 15: 1446-1457, 2008.
  92. Gruszauskas N, Drukker K, Giger ML, Sennett CA, Pesce LL: Performance of breast ultrasound computer-aided diagnosis: Dependence on image selection, Academic Radiology 15: 1234-1245, 2008.
  93. Li H, Giger ML, Yuan Y, Chen W, Horsch K, Lan L, Jamieson A, Sennett CA, Jansen SA: Evaluation of Computerized Diagnosis Scheme on a Large Clinical Full-Field Digital Mammographic Dataset. Academic Radiology 15: 1437-1445, 2008.
  94. Yuan Y, Giger ML, Li H, Sennett C: Correlative feature analysis on FFDM. Medical Physics 35: 5490-5500, 2008.
  95. Giger ML, Chan H-P, Boone J: Anniversary Paper: History and status of CAD and quantitative image analysis: The role of Medical Physics and AAPM. Medical Physics 35: 5799-5820, 2008.
  96. Drukker K, Sennett CA, Giger ML: Automated method for improving system performance of computer-aided diagnosis in breast ultrasound. IEEE Transactions in Medical Imaging (TMI) 28: 122-128, 2009.
  97. Gruszauskas NP, Drukker K, Giger ML, Chang R-F, Sennett CA, Moon WK, Pesce LL. Breast US computer-aided diagnosis system: Robustness across urban populations in South Korea and the United States. Radiology 253: 661- 671, 2009.
  98. Bhooshan N, Giger ML, Jansen S, Li H, Lan L, Newstead G: Image-based Prognostic Markers from Computerized Characterization of a Clinical Breast MRI Database. Radiology 254: 680-690, 2010.
  99. Jamieson A, Giger ML, Drukker K, Li H, Yuan Y, Bhooshan N: Exploring non-linear feature space dimension reduction and data representation in breast CADx with Laplacian eigenmaps and t-SNE. Medical Physics 37: 339-351, 2010.
  100. Chen W, Metz CE, Giger ML, Drukker K: A novel hybrid linear/nonlinear classifier for two-class classification: Theory, algorithm, and applications. IEEE Trans Med Imag 29: 428-441, 2010.
  101. Vokes T, Lauderdale D, Ma S-L, Chinander M, Giger ML: Radiographic texture analysis of densitometric calcaneal images – relationship to clinical characteristics and to bone fragility. J Bone & Mineral Research 25: 56-63, 2010.
  102. Shimauchi A, Giger ML, Bhooshan N, Lan L, Chen W, Lee J, Abe H, Newstead G: Reader study for the evaluation of radiologists’ interpretation of clinical breast MRI using a CAD breast MRI workstation. Radiology (in press).
  103. Chen W, Giger ML, Newstead GM, Bick U, Sanaz SA, Li H, Lan L: Computerized assessment of breast lesion malignancy using DCE-MRI: Robustness study on two independent clinical datasets from two manufacturers. Academic Radiology 17: 822-829, 2010.
  104. Drukker K, Pesce L, Giger ML: Repeatability in computer-aided diagnosis: Application to breast cancer diagnosis on sonography. Medical Physics 37: 2659-2669, 2010.
  105. Yuan Y, Giger ML, Li H, Bhooshan N, Sennett CA: Multi-modality computer-aided breast cancer diagnosis with FFDM and DCE-MRI. Academic Radiology 17: 1158-1167, 2010.
  106. Jamieson AR, Giger ML, Drukker K, Pesce L: Enhancement of breast CADx with unlabeled data. Medical Physics 37: 4155-4172, 2010 [also listed in Virtual Journal of Biological Physics Research, August 1, 2010]
  107. King M, Rodgers Z, Giger ML, Bardo DME, Patel A: Computerized method for evaluating diagnostic image quality of calcified plaque images in cardiac CT: Validation on a physical dynamic cardiac phantom. Medical Physics 37: 5777-5786, 2010.
  108. Bhooshan N, Giger ML, Lan L, Li H, Marquez A, Shimauchi A, Newstead GM: Using T2-weighted MRI in the Automated Analysis of Breast Lesions. Magnetic Resonance in Medicine 66:555-564. 2011.
  109. Gallas BD, Chan H-P, D'Orsi CJ, Dodd LE, Giger ML, Gur D, Krupinski EA, Metz CE, Myers KJ, Obuchowski NA, Sahiner B, Toledano AY, Zuley ML. Evaluating imaging and computer-aided detection and diagnosis devices at the FDA. Academic Radiology 19: 463-477, 2012.
  110. Yuan Y, Giger ML, Li H, Bhooshan N, Sennett CA.  Correlative analysis of FFDM and DCE-MRI for improved breast CADx. Journal of Medical and Biological Engineering 32: 42-50, 2012.
  111. Bhooshan N, Giger ML, Medved M, Wood A, Yuan Y, Lan L, Marquez A, Li H, Newstead G, Karczmar G.  Potential of computer-aided diagnosis of high spectral and spatial resolution (HiSS) MRI in the classification of breast lesions.  Journal of Magnetic Resonance Imaging (in press).
  112. Bhooshan N, Giger ML, Metz CE, Li H, Jansen SA, Lan L, Newstead GM.  Integrated computer-extracted MRI-based biomarkers for breast cancer survival prediction. (under preparation).

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