People

Patrick J. La Riviere, PhD

My lab develops algorithms and algorithm-enabled imaging systems at scales from nanometers (x-ray microscopy) to meters (human computed tomography). Themes that span all scales and modalities include dose reduction, material identification, and orientation imaging.

University of Chicago
Chicago, IL
Ph.D. - Medical Physics
2000

Cambridge University
Cambridge, UK
- Philosophy of physics
1995

Harvard University
Cambridge, MA
A.B. - Physics
1994

Synergistic checkpoint-blockade and radiotherapy-radiodynamic therapy via an immunomodulatory nanoscale metal-organic framework.
Ni K, Xu Z, Culbert A, Luo T, Guo N, Yang K, Pearson E, Preusser B, Wu T, La Riviere P, Weichselbaum RR, Spiotto MT, Lin W. Synergistic checkpoint-blockade and radiotherapy-radiodynamic therapy via an immunomodulatory nanoscale metal-organic framework. Nat Biomed Eng. 2022 02; 6(2):144-156.
PMID: 35190678

A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale.
Yakovlev MA, Vanselow DJ, Ngu MS, Zaino CR, Katz SR, Ding Y, Parkinson D, Wang SY, Ang KC, La Riviere P, Cheng KC. A wide-field micro-computed tomography detector: micron resolution at half-centimetre scale. J Synchrotron Radiat. 2022 Mar 01; 29(Pt 2):505-514.
PMID: 35254315

Uncovering the Effects of Symbiosis and Temperature on Coral Calcification.
Dellaert Z, Vargas PA, La Riviere PJ, Roberson LM. Uncovering the Effects of Symbiosis and Temperature on Coral Calcification. Biol Bull. 2022 02; 242(1):62-73.
PMID: 35245159

Multiview confocal super-resolution microscopy.
Wu Y, Han X, Su Y, Glidewell M, Daniels JS, Liu J, Sengupta T, Rey-Suarez I, Fischer R, Patel A, Combs C, Sun J, Wu X, Christensen R, Smith C, Bao L, Sun Y, Duncan LH, Chen J, Pommier Y, Shi YB, Murphy E, Roy S, Upadhyaya A, Colón-Ramos D, La Riviere P, Shroff H. Multiview confocal super-resolution microscopy. Nature. 2021 12; 600(7888):279-284.
PMID: 34837071

From EMI to AI: a brief history of commercial CT reconstruction algorithms.
La Riviere PJ, Crawford CR. From EMI to AI: a brief history of commercial CT reconstruction algorithms. J Med Imaging (Bellingham). 2021 Sep; 8(5):052111.
PMID: 34660842

Low-Dose High-Resolution TOF-PET Using Ionization-activated Multi-State Low-Z Detector Media.
Shida JF, Spieglan E, Adams BW, Angelico E, Domurat-Sousa K, Elagin A, Frisch HJ, La Riviere P, Squires AH. Low-Dose High-Resolution TOF-PET Using Ionization-activated Multi-State Low-Z Detector Media. Nucl Instrum Methods Phys Res A. 2021 Nov 21; 1017.
PMID: 34690392

Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution.
Foxley S, Sampathkumar V, De Andrade V, Trinkle S, Sorokina A, Norwood K, La Riviere P, Kasthuri N. Multi-modal imaging of a single mouse brain over five orders of magnitude of resolution. Neuroimage. 2021 09; 238:118250.
PMID: 34116154

Rapid image deconvolution and multiview fusion for optical microscopy.
Guo M, Li Y, Su Y, Lambert T, Nogare DD, Moyle MW, Duncan LH, Ikegami R, Santella A, Rey-Suarez I, Green D, Beiriger A, Chen J, Vishwasrao H, Ganesan S, Prince V, Waters JC, Annunziata CM, Hafner M, Mohler WA, Chitnis AB, Upadhyaya A, Usdin TB, Bao Z, Colón-Ramos D, La Riviere P, Liu H, Wu Y, Shroff H. Rapid image deconvolution and multiview fusion for optical microscopy. Nat Biotechnol. 2020 11; 38(11):1337-1346.
PMID: 32601431

Transforming the development and dissemination of cutting-edge microscopy and computation.
Colón-Ramos DA, La Riviere P, Shroff H, Oldenbourg R. Transforming the development and dissemination of cutting-edge microscopy and computation. Nat Methods. 2019 08; 16(8):667-669.
PMID: 31363203

Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography.
Ding Y, Vanselow DJ, Yakovlev MA, Katz SR, Lin AY, Clark DP, Vargas P, Xin X, Copper JE, Canfield VA, Ang KC, Wang Y, Xiao X, De Carlo F, van Rossum DB, La Riviere P, Cheng KC. Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography. Elife. 2019 05 07; 8.
PMID: 31063133

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Distinguished investigator
Academy for Radiology and Biomedical Imaging Research
2018

Fellow
Marine Biological Laboratory
2016

Young Investigator Medical Imaging Scientist Award
IEEE
2005

Lionel deJersey Harvard Scholarship to Cambridge University
Harvard University
1994