People

Patrick J. La Riviere, PhD

My lab develops algorithms and algorithm-enabled imaging systems at scales from nanometers (x-ray microscopy) to meters (human computed tomography). Themes that span all scales and modalities include dose reduction, material identification, and orientation imaging.

University of Chicago
Chicago, IL
Ph.D. - Medical Physics
2000

Cambridge University
Cambridge, UK
- Philosophy of physics
1995

Harvard University
Cambridge, MA
A.B. - Physics
1994

Transforming the development and dissemination of cutting-edge microscopy and computation.
Colón-Ramos DA, La Riviere P, Shroff H, Oldenbourg R. Transforming the development and dissemination of cutting-edge microscopy and computation. Nat Methods. 2019 08; 16(8):667-669.
PMID: 31363203

Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography.
Ding Y, Vanselow DJ, Yakovlev MA, Katz SR, Lin AY, Clark DP, Vargas P, Xin X, Copper JE, Canfield VA, Ang KC, Wang Y, Xiao X, De Carlo F, van Rossum DB, La Riviere P, Cheng KC. Computational 3D histological phenotyping of whole zebrafish by X-ray histotomography. Elife. 2019 05 07; 8.
PMID: 31063133

Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy.
Ni K, Lan G, Chan C, Quigley B, Lu K, Aung T, Guo N, La Riviere P, Weichselbaum RR, Lin W. Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun. 2018 06 15; 9(1):2351.
PMID: 29907739

An early chondrichthyan and the evolutionary assembly of a shark body plan.
Coates MI, Finarelli JA, Sansom IJ, Andreev PS, Criswell KE, Tietjen K, Rivers ML, La Riviere PJ. An early chondrichthyan and the evolutionary assembly of a shark body plan. Proc Biol Sci. 2018 01 10; 285(1870).
PMID: 29298937

Single-fluorophore orientation determination with multiview polarized illumination: modeling and microscope design.
Chandler T, Mehta S, Shroff H, Oldenbourg R, La Rivière PJ. Single-fluorophore orientation determination with multiview polarized illumination: modeling and microscope design. Opt Express. 2017 Dec 11; 25(25):31309-31325.
PMID: 29245807

Reflective imaging improves spatiotemporal resolution and collection efficiency in light sheet microscopy.
Wu Y, Kumar A, Smith C, Ardiel E, Chandris P, Christensen R, Rey-Suarez I, Guo M, Vishwasrao HD, Chen J, Tang J, Upadhyaya A, La Riviere PJ, Shroff H. Reflective imaging improves spatiotemporal resolution and collection efficiency in light sheet microscopy. Nat Commun. 2017 11 13; 8(1):1452.
PMID: 29129912

Sensitivity evaluation and selective plane imaging geometry for x-ray-induced luminescence imaging.
Quigley BP, Smith CD, Cheng SH, Souris JS, Pelizzari CA, Chen CT, Lo LW, Reft CS, Wiersma RD, La Riviere PJ. Sensitivity evaluation and selective plane imaging geometry for x-ray-induced luminescence imaging. Med Phys. 2017 Oct; 44(10):5367-5377.
PMID: 28703922

Improved deconvolution of very weak confocal signals.
Day KJ, La Rivière PJ, Chandler T, Bindokas VP, Ferrier NJ, Glick BS. Improved deconvolution of very weak confocal signals. F1000Res. 2017; 6:787.
PMID: 28868135

Variable temporal sampling and tube current modulation for myocardial blood flow estimation from dose-reduced dynamic computed tomography.
Modgil D, Bindschadler MD, Alessio AM, La Rivière PJ. Variable temporal sampling and tube current modulation for myocardial blood flow estimation from dose-reduced dynamic computed tomography. J Med Imaging (Bellingham). 2017 Apr; 4(2):026002.
PMID: 28523283

Assessment of vectorial total variation penalties on realistic dual-energy CT data.
Rigie DS, Sanchez AA, La Rivière PJ. Assessment of vectorial total variation penalties on realistic dual-energy CT data. Phys Med Biol. 2017 04 21; 62(8):3284-3298.
PMID: 28350547

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Distinguished investigator
Academy for Radiology and Biomedical Imaging Research
2018

Fellow
Marine Biological Laboratory
2016

Young Investigator Medical Imaging Scientist Award
IEEE
2005

Lionel deJersey Harvard Scholarship to Cambridge University
Harvard University
1994