Dr. Chen's research interests, primarily in integrative multi-modality molecular imaging, cover a broad spectrum of imaging-centered topics including imaging physics and instrumentation, image reconstruction and processing, imaging tracers and probes development, physiological modeling, quantitative and intelligent image analysis, as well as applications of molecular imaging methods in a wide spectrum of biological and medical investigations, especially in cancer, brain disorders, cardiopulmonary diseases, and diabetes.
The University of Chicago
Chicago, Illinois
PhD - Medical Physics
1986
Northwester University
Evanston, Illinois
MS - Physics
1978
National Tsing-Hua University
Hsinchu, Taiwan
BS - Physics
1974
Development of a PET radioligand for potassium channels to image CNS demyelination.
Development of a PET radioligand for potassium channels to image CNS demyelination. Sci Rep. 2018 01 12; 8(1):607.
PMID: 29330383
Sensitivity evaluation and selective plane imaging geometry for x-ray-induced luminescence imaging.
Sensitivity evaluation and selective plane imaging geometry for x-ray-induced luminescence imaging. Med Phys. 2017 Oct; 44(10):5367-5377.
PMID: 28703922
Lectin-functionalized mesoporous silica nanoparticles for endoscopic detection of premalignant colonic lesions.
Lectin-functionalized mesoporous silica nanoparticles for endoscopic detection of premalignant colonic lesions. Nanomedicine. 2017 Aug; 13(6):1941-1952.
PMID: 28363770
Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma.
Dynamic In Vivo SPECT Imaging of Neural Stem Cells Functionalized with Radiolabeled Nanoparticles for Tracking of Glioblastoma. J Nucl Med. 2016 Feb; 57(2):279-84.
PMID: 26564318
Lung cancer-a fractal viewpoint.
Lung cancer-a fractal viewpoint. Nat Rev Clin Oncol. 2015 Nov; 12(11):664-75.
PMID: 26169924
Radioluminescence characterization of in situ x-ray nanodosimeters: Potential real-time monitors and modulators of external beam radiation therapy.
Radioluminescence characterization of in situ x-ray nanodosimeters: Potential real-time monitors and modulators of external beam radiation therapy. Appl Phys Lett. 2014 Nov 17; 105(20):203110.
PMID: 25425747
The vanadyl chelate bis(acetylacetonato)oxovanadium(IV) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-D-glucose by cultured human breast carcinoma cells.
The vanadyl chelate bis(acetylacetonato)oxovanadium(IV) increases the fractional uptake of 2-(fluorine-18)-2-deoxy-D-glucose by cultured human breast carcinoma cells. Dalton Trans. 2013 Sep 07; 42(33):11862-7.
PMID: 23644715
Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy.
Nanoparticle-programmed self-destructive neural stem cells for glioblastoma targeting and therapy. Small. 2013 Dec 20; 9(24):4123-9.
PMID: 23873826
PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension.
PGC1a-mediated mitofusin-2 deficiency in female rats and humans with pulmonary arterial hypertension. Am J Respir Crit Care Med. 2013 Apr 15; 187(8):865-78.
PMID: 23449689
Flexible peritoneal windows for quantitative fluorescence and bioluminescence preclinical imaging.
Flexible peritoneal windows for quantitative fluorescence and bioluminescence preclinical imaging. Mol Imaging. 2013 Jan-Feb; 12(1):28-38.
PMID: 23348789